Hey there, if you create and delete some aliasses for different domains, letsencrypt creates a new folder `/etc/letsencrypt/live/domain.tld-0001/` instead of `/etc/letsencrypt/live/domain.tld/`, but ISPConfig is always using the folder `/etc/letsencrypt/live/domain.tld/`. You can solve this problem by requesting the correct folder path with following command (please use latest certbot script): `certbot certificates` See also: https://github.com/certbot/certbot/issues/3395